Article
Conservation of coevolving protein interfaces bridges prokaryote-eukaryote homologies in the twilight zone.
Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2016
Rodriguez-Rivas Juan, Marsili Simone, Juan David, Valencia Alfonso
Abstract excerpt
Protein-protein interactions are fundamental for the proper functioning of the cell. As a result, protein interaction surfaces are subject to strong evolutionary constraints. Recent developments have shown that residue coevolution provides accurate predictions of heterodimeric protein interfaces from sequence information. So far these approaches have been limited to the analysis of families of prokaryotic...
Topics
- Biological Evolution
- Catalytic Domain
- Computational Biology
- Databases, Protein
- Eukaryota
- Evolution, Molecular
- Humans
- Models, Statistical
- Mutation
- Prokaryotic Cells
- Protein Binding
- Protein Interaction Mapping
- Protein Multimerization
- Proteins