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Article

Epistasis-Driven Evolution of the SARS-CoV-2 Secondary Structure.

Journal of molecular evolution - 1 Dec 2022

Alemrajabi Mahsa, Macias Calix Ksenia, Assis Raquel

Abstract excerpt

Epistasis is an evolutionary phenomenon whereby the fitness effect of a mutation depends on the genetic background in which it arises. A key source of epistasis in an RNA molecule is its secondary structure, which contains functionally important topological motifs held together by hydrogen bonds between Watson-Crick (WC) base pairs. Here we study epistasis in the secondary structure of severe acute respiratory...

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Identifiers

PMID: 36178491
DOI: 10.1007/s00239-022-10073-1
PMCID: PMC9523185

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