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Article

Irradiation selects for p53-deficient hematopoietic progenitors.

PLoS biology - 2 Mar 2010

Marusyk Andriy, Porter Christopher C, Zaberezhnyy Vadym, DeGregori James

Abstract excerpt

Identification and characterization of mutations that drive cancer evolution constitute a major focus of cancer research. Consequently, dominant paradigms attribute the tumorigenic effects of carcinogens in general and ionizing radiation in particular to their direct mutagenic action on genetic loci encoding oncogenes and tumor suppressor genes. However, the effects of irradiation are not limited to genetic loci...

Topics

Animals
Biomarkers
Bone Marrow Transplantation
Cells, Cultured
DNA Damage
Genes, p53
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells
Lymphoma
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Knockout

Mutation

Radiation, Ionizing

Recombinant Fusion Proteins

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 20208998
DOI: 10.1371/journal.pbio.1000324
PMCID: PMC2830447

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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