Back to search

Article

Programmed Clonal Expansion Associated with V(D)J Recombination Drives an ATM-Dependent Vulnerability Underlying Preferential Lymphocyte Depletion and Myeloid Bias Following DNA Damage

2026-08-11

Abstract excerpt

Myeloid bias is a hallmark of aging and genotoxic stress, yet the mechanisms underlying the preferential suppression of lymphopoiesis and the resulting predominance of myeloid cells following DNA damage remain incompletely understood. Here, we systematically characterized the acute hematopoietic response to a clinically relevant 2 Gy dose of ionizing radiation in young adult mice. Forty-eight hours after irradiati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b9b38abe-e328-50ef-92a0-66991d005793
DOI
10.64898/2026.08.05.743027
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Programmed Clonal Expansion Associated with V(D)J Recombination Drives an ATM-Dependent Vulnerability Underlying Preferential Lymphocyte Depletion and Myeloid Bias Following DNA DamageDOI 10.64898/2026.08.05.743027
Lifelong Residual bone Marrow Damage in Murine Survivors of the Hematopoietic Acute Radiation Syndrome (H-ARS): A Compilation of Studies Comprising the Indiana University ExperienceSemantic proximity
Sublethal Total Body Irradiation Causes Long-Term Deficits in Thymus Function by Reducing Lymphoid ProgenitorsSemantic proximity
Effect of Age at Time of Irradiation, Sex, Genetic Diversity, and Granulopoietic Cytokine Radiomitigation on Lifespan and Lymphoma Development in Murine H-ARS Survivors.Semantic proximity
Age and Sex Divergence in Hematopoietic Radiosensitivity in Aged Mouse Models of the Hematopoietic Acute Radiation SyndromeSemantic proximity
The repair of DNA damages/modifications during the maturation of the immune system: lessons from human primary immunodeficiency disorders and animal models.Semantic proximity
Kitlo hematopoietic stem cells exhibit distinct lymphoid-primed chromatin landscapes that enhance thymic reconstitutionSemantic proximity
DNA damage and repair during lymphoid development: antigen receptor diversity, genomic integrity and lymphomagenesis.Semantic proximity
Impact of Age, Sex, and Genetic Diversity in Murine Models of the Hematopoietic Acute Radiation Syndrome (H-ARS) and the Delayed Effects of Acute Radiation Exposure (DEARE)Semantic proximity
Spectra and characteristics of somatic mutations induced by ionizing radiation in hematopoietic stem cells.Semantic proximity
Irradiation alters selection for oncogenic mutations in hematopoietic progenitors.Semantic proximity
DNA-damage response in hematopoietic stem cells: an evolutionary trade-off between blood regeneration and leukemia suppressionSemantic proximity
Transcriptomic alterations including p53 pathway dysregulation prime DNMT3A mutant cells for transformationSemantic proximity
Select a neighboring publication to make it the new centre.