Article
Association of induction of a fully tumorigenic phenotype in murine radiation-induced T-lymphoma cells with loss of differentiation antigens, gain of CD44, and alterations in p53 protein levels.
Molecular carcinogenesis - 1 Jan 1992
Gjerset R A, Arya J, Volkman S, Haas M
Abstract excerpt
We investigated the mechanism of radiation induction of murine thymic lymphomas by studying the characteristics of primary x-ray-induced thymic lymphoma (PXTL) cell lines and of their oncogene-induced, progressed progeny. It is widely thought that proto-oncogene alterations are associated with the induction of murine lymphomas; however, few, if any primary murine radiation-induced lymphomas possess...
Topics
- Animals
- Antigens, Differentiation
- Bone Marrow
- Cell Line
- Clone Cells
- Leukemia, Radiation-Induced
- Lymphoma, T-Cell
- Mice
- Mice, Inbred C57BL
- Models, Biological
- Oncogenes