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Article

Susceptibility to radiation-carcinogenesis and accumulation of chromosomal breakage in p53 deficient mice.

Oncogene - 1 Dec 1994

Lee J M, Abrahamson J L, Kandel R, Donehower L A, Bernstein A

Abstract excerpt

The p53 tumour suppressor gene is an important participant in the cellular response to ionizing radiation and other DNA damaging agents. Cells which lack p53 are unable to arrest cell cycle or enter into apoptotic cell death following irradiation. Moreover, these p53 deficient cells exhibit an increased resistance to DNA damaging agents, including radiation. The significance of this radiation-resistance and its...

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Identifiers

PMID: 7970733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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