Article
Susceptibility to radiation-carcinogenesis and accumulation of chromosomal breakage in p53 deficient mice.
Oncogene - 1 Dec 1994
Lee J M, Abrahamson J L, Kandel R, Donehower L A, Bernstein A
Abstract excerpt
The p53 tumour suppressor gene is an important participant in the cellular response to ionizing radiation and other DNA damaging agents. Cells which lack p53 are unable to arrest cell cycle or enter into apoptotic cell death following irradiation. Moreover, these p53 deficient cells exhibit an in...
Topics
- Animals
- Chromosome Aberrations
- DNA Damage
- Genes, p53
- Genetic Predisposition to Disease
- Mice
- Mice, Transgenic
- Neoplasms, Radiation-Induced