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Article

Irradiation alters selection for oncogenic mutations in hematopoietic progenitors.

Cancer research - 15 Sept 2009

Marusyk Andriy, Casás-Selves Matias, Henry Curtis J, Zaberezhnyy Vadym, Klawitter Jelena, Christians Uwe, DeGregori James

Abstract excerpt

Exposure to ionizing radiation and other DNA-damaging carcinogens is strongly associated with induction of malignancies. Prevailing paradigms attribute this association to the induction of oncogenic mutations, as the incidence of oncogenic events is thought to limit initiation and progression of cancers. On the other hand, random mutagenic and genotoxic effects of irradiation are likely to alter progenitor cell...

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Identifiers

PMID: 19738065
DOI: 10.1158/0008-5472.CAN-09-0604
PMCID: PMC2745506

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