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Article

Role of genetics, environment, and their interactions in the pathogenesis of eosinophilic esophagitis.

Current opinion in immunology - 1 Oct 2019

Lyles John, Rothenberg Marc

Abstract excerpt

The rise in incidence and prevalence of eosinophilic esophagitis (EoE) since the 1990s has prompted investigations into its pathogenesis, natural history, and management. Identified genetic variants in FLG, DSG1, CAPN14, SPINK5, and SPINK7 link EoE to epithelial barrier dysfunction, whereas variants in CCL26, POSTN, and TSLP associate EoE with T helper type 2-mediated immunity. Early-life, infectious, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31132551
DOI: 10.1016/j.coi.2019.04.004
PMCID: PMC6800613

Genes

CAPN14
CCL26
DSG1
FLG
POSTN
SPINK5
SPINK7
TSLP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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