Article
Pathogenesis of Eosinophilic Esophagitis: A Comprehensive Review of the Genetic and Molecular Aspects.
International journal of molecular sciences - 30 Sept 2020
Ryu Seohyun, Lee Keum Hwa, Tizaoui Kalthoum, Terrazzino Salvatore, Cargnin Sarah, Effenberger Maria, Shin Jae Il, Kronbichler Andreas
Abstract excerpt
Eosinophilic esophagitis (EoE) is a relatively new condition described as an allergic-mediated disease of the esophagus. Clinically, it is characterized by dysphagia, food impaction, and reflux-like symptoms. Multiple genome-wide association studies (GWAS) have been conducted to identify genetic loci associated with EoE. The integration of numerous studies investigating the genetic polymorphisms in EoE and the...
Topics
- Calpain
- Chemokine CCL26
- Cytokines
- Eosinophilic Esophagitis
- Esophagus
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Hypersensitivity
- Interleukin-13