Article
Replication and meta-analyses nominate numerous eosinophilic esophagitis risk genes.
The Journal of allergy and clinical immunology - 1 Jan 2021
Kottyan Leah C, Trimarchi Michael P, Lu Xiaoming, Caldwell Julie M, Maddox Avery, Parameswaran Sreeja, Lape Michael, D'Mello Rahul J, Bonfield Madeline, Ballaban Adina, Mukkada Vincent, Putnam Philip E, Abonia Pablo, Ben-Baruch Morgenstern Netali, Eapen Amy A, Wen Ting, Weirauch Matthew T, Rothenberg Marc E
Abstract excerpt
BACKGROUND: Eosinophilic esophagitis (EoE) is an emerging, chronic, rare allergic disease associated with marked eosinophil accumulation in the esophagus. Previous genome-wide association studies have provided strong evidence for 3 genome-wide susceptibility loci. OBJECTIVE: We sought to replicate known and suggestive EoE genetic risk loci and conduct a meta-analysis of previously reported data sets. METHODS: An...
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