Article
Multitrait analysis of genome-wide association studies expands eosinophilic esophagitis genetic susceptibility and polygenic risk scores.
The Journal of allergy and clinical immunology - 1 Aug 2026
Trimarchi Michael P, Namjou-Khales Bahram, Ben-Baruch Morgenstern Netali, Rochman Mark, Chen Xiaoting, Osswald Garrett A, Besse John A, Shook Molly S, Caldwell Julie M, Lape Michael, Shoda Tetsuo, Weirauch Matthew T, Ruffner Melanie A, Constantine Gregory M, Martin Lisa J, Kottyan Leah C, Rothenberg Marc E
Abstract excerpt
BACKGROUND: Eosinophilic esophagitis (EoE) is an atopic disease driven in part by genetic susceptibility, but single-trait genome-wide association study (GWAS) has identified a limited number of genome-wide significant risk loci. OBJECTIVE: We sought to expand discovery of EoE genetic risk loci by leveraging shared genetic architecture with other atopic diseases and to develop a polygenic risk score (PRS) for...
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