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Article

GWAS identifies four novel eosinophilic esophagitis loci.

Nature communications - 19 Nov 2014

Sleiman Patrick M A, Wang Mei-Lun, Cianferoni Antonella, Aceves Seema, Gonsalves Nirmala, Nadeau Kari, Bredenoord Albert J, Furuta Glenn T, Spergel Jonathan M, Hakonarson Hakon

Abstract excerpt

Eosinophilic esophagitis (EoE) is an allergic disorder characterized by infiltration of the oesophagus with eosinophils. We had previously reported association of the TSLP/WDR36 locus with EoE. Here we report genome-wide significant associations at four additional loci; c11orf30 and STAT6, which have been previously associated with both atopic and autoimmune diseases, and two EoE-specific loci, ANKRD27 that...

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Source

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Identifiers

PMID: 25407941
DOI: 10.1038/ncomms6593
PMCID: PMC4238044

Genes

CAPN14
STAT6
TSLP

Provenance

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