Article
HLA-DRB1 allele heterogeneity influences multiple sclerosis severity as well as risk in Western Australia.
Journal of neuroimmunology - 26 Feb 2010
Wu Jing-Shan, James Ian, Qiu Wei, Castley Alison, Christiansen Frank T, Carroll William M, Mastaglia Frank L, Kermode Allan G
Abstract excerpt
Susceptibility to multiple sclerosis (MS) has been consistently associated with the Human Leukocyte Antigen (HLA)-DRB11501 genotype, however effects on disease severity and clinical outcome have varied in different populations. We present the results of a high-resolution HLA-DRB1 genotyping and genotype-phenotype correlation study in a large West Australian MS cohort. Our findings indicate that in this...
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