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Article

Modifying effects of HLA-DRB1 allele interactions on age at onset of multiple sclerosis in Western Australia.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Jan 2010

Wu Jing-Shan, Qiu Wei, Castley Alison, James Ian, Mastaglia Frank L, Christiansen Frank T, Carroll William M, Joseph Joyce, Kermode Allan G

Abstract excerpt

The contribution of genetic factors to the age at onset in multiple sclerosis is poorly understood. Our objective was to investigate the disease modifying effects of HLA-DRB1 alleles and allele interactions on age at onset of multiple sclerosis. High-resolution four-digit HLA-DRB1 genotyping was performed in a cohort of 461 multiple sclerosis patients from the Perth Demyelinating Diseases Database. Carriage of...

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Source

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PMID: 19995849
DOI: 10.1177/1352458509350312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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