Article
An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus.
Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2007
DeLuca G C, Ramagopalan S V, Herrera B M, Dyment D A, Lincoln M R, Montpetit A, Pugliatti M, Barnardo M C N, Risch N J, Sadovnick A D, Chao M, Sotgiu S, Hudson T J, Ebers G C
Abstract excerpt
Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed for variability in disease outcome. A cohort of sporadic MS cases (n = 163), taken from opposite extremes of the distribution of long-term outcome, was used to determine the role of the HLA-DRB1 locus on MS disease severity. Genotyping sets of benign and malignant MS patients showed that HLA-DRB1*01 was...
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