Article
Clustering by genetic ancestry using genome-wide SNP data.
BMC genetics - 9 Dec 2010
Solovieff Nadia, Hartley Stephen W, Baldwin Clinton T, Perls Thomas T, Steinberg Martin H, Sebastiani Paola
Abstract excerpt
BACKGROUND: Population stratification can cause spurious associations in a genome-wide association study (GWAS), and occurs when differences in allele frequencies of single nucleotide polymorphisms (SNPs) are due to ancestral differences between cases and controls rather than the trait of interest. Principal components analysis (PCA) is the established approach to detect population substructure using genome-wide...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.