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Article

A metastasis or a second independent cancer? Evaluating the clonal origin of tumors using array copy number data.

Statistics in medicine - 10 Jul 2010

Ostrovnaya Irina, Olshen Adam B, Seshan Venkatraman E, Orlow Irene, Albertson Donna G, Begg Colin B

Abstract excerpt

When a cancer patient develops a new tumor it is necessary to determine if it is a recurrence (metastasis) of the original cancer, or an entirely new occurrence of the disease. This is accomplished by assessing the histo-pathology of the lesions. However, there are many clinical scenarios in which this pathological diagnosis is difficult. Since each tumor is characterized by a distinct pattern of somatic...

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Identifiers

PMID: 20205270
DOI: 10.1002/sim.3866
PMCID: PMC3145177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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