Article
Clinicopathological features of CpG island methylator phenotype-positive colorectal cancer and its adverse prognosis in relation to KRAS/BRAF mutation.
Pathology international - 1 Feb 2008
Lee Sun, Cho Nam-Yun, Choi Minhee, Yoo Eun J, Kim Jung-Ho, Kang Gyeong H
Abstract excerpt
CpG island methylator phenotype (CIMP) is a recently described subset of colorectal cancers (CRC) with widespread methylation of multiple promoter CpG islands. But the prognostic implication of CIMP in CRC has not been clarified. Thus, the aim of the present study was to differentiate the unique...
Topics
- Adenocarcinoma
- Colorectal Neoplasms
- CpG Islands
- DNA Methylation
- DNA Mutational Analysis
- DNA, Neoplasm
- Female
- Gene Expression Regulation, Neoplastic
- Genomic Instability
- Humans
- Male
- Microsatellite Repeats
- Middle Aged
- Mutation
- Prognosis
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins B-raf
- Proto-Oncogene Proteins p21(ras)