Article
Regulatory polymorphisms in EGR2 are associated with susceptibility to systemic lupus erythematosus.
Human molecular genetics - 1 Jun 2010
Myouzen Keiko, Kochi Yuta, Shimane Kenichi, Fujio Keishi, Okamura Tomohisa, Okada Yukinori, Suzuki Akari, Atsumi Tatsuya, Ito Satoshi, Takada Kazuki, Mimori Akio, Ikegawa Shiro, Yamada Ryo, Nakamura Yusuke, Yamamoto Kazuhiko
Abstract excerpt
Systemic lupus erythematosus (SLE) is an autoimmune disease induced by the combinations of environmental and genetic factors. Recently, mice in which the early growth response 2 (EGR2) gene, a zinc-finger transcription factor, is conditionally knocked out in CD2(+) T cells have been shown to develop a lupus-like autoimmune disease. Here, we evaluated if polymorphisms in the EGR2 gene influence SLE susceptibility...
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