Article
A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese.
PLoS genetics - 1 Jan 2012
Okada Yukinori, Shimane Kenichi, Kochi Yuta, Tahira Tomoko, Suzuki Akari, Higasa Koichiro, Takahashi Atsushi, Horita Tetsuya, Atsumi Tatsuya, Ishii Tomonori, Okamoto Akiko, Fujio Keishi, Hirakata Michito, Amano Hirofumi, Kondo Yuya, Ito Satoshi, Takada Kazuki, Mimori Akio, Saito Kazuyoshi, Kamachi Makoto, Kawaguchi Yasushi, Ikari Katsunori, Mohammed Osman Wael, Matsuda Koichi, Terao Chikashi, Ohmura Koichiro, Myouzen Keiko, Hosono Naoya, Tsunoda Tatsuhiko, Nishimoto Norihiro, Mimori Tsuneyo, Matsuda Fumihiko, Tanaka Yoshiya, Sumida Takayuki, Yamanaka Hisashi, Takasaki Yoshinari, Koike Takao, Horiuchi Takahiko, Hayashi Kenshi, Kubo Michiaki, Kamatani Naoyuki, Yamada Ryo, Nakamura Yusuke, Yamamoto Kazuhiko
Abstract excerpt
Systemic lupus erythematosus (SLE) is an autoimmune disease that causes multiple organ damage. Although recent genome-wide association studies (GWAS) have contributed to discovery of SLE susceptibility genes, few studies has been performed in Asian populations. Here, we report a GWAS for SLE examining 891 SLE cases and 3,384 controls and multi-stage replication studies examining 1,387 SLE cases and 28,564...
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