Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.

doi:10.1086/428480

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Article

Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.

American journal of human genetics - 1 Mar 2005

Sigurdsson Snaevar, Nordmark Gunnel, Göring Harald H H, Lindroos Katarina, Wiman Ann-Christin, Sturfelt Gunnar, Jönsen Andreas, Rantapää-Dahlqvist Solbritt, Möller Bozena, Kere Juha, Koskenmies Sari, Widén Elisabeth, Eloranta Maija-Leena, Julkunen Heikki, Kristjansdottir Helga, Steinsson Kristjan, Alm Gunnar, Rönnblom Lars, Syvänen Ann-Christine

Abstract excerpt

Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease caused by both genetic and environmental factors. Genome scans in families with SLE point to multiple potential chromosomal regions that harbor SLE susceptibility genes, and association studies in different populations have suggested several susceptibility alleles for SLE. Increased production of type I interferon (IFN) and expression of...

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PMID: 15657875
DOI: 10.1086/428480
PMCID: PMC1196404

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TYK2

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