Article
Gene expression and regulation in systemic lupus erythematosus.
European journal of clinical investigation - 1 Oct 2013
Frangou Eleni A, Bertsias George K, Boumpas Dimitrios T
Abstract excerpt
BACKGROUND: Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune disease. Genome-wide (GW) association studies have identified more than 40 disease-associated loci, together accounting for only 10-20% of disease heritability. Gene expression represents the intermediate phenotype between DNA and disease phenotypic variation, and provides insights regarding genetic and epigenetic effects. We...
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