Article
Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotype.
The Journal of biological chemistry - 16 Apr 2010
Borikova Asya L, Dibble Christopher F, Sciaky Noah, Welch Christopher M, Abell Amy N, Bencharit Sompop, Johnson Gary L
Abstract excerpt
Cerebral cavernous malformations (CCM) are vascular lesions causing seizures and stroke. Mutations causing inactivation of one of three genes, ccm1, -2, or -3, are sufficient to induce vascular endothelial cell defects resulting in CCM. Herein, we show that loss of expression of the CCM1, -2, or -3 proteins causes a marked increase in expression of the GTPase RhoA. Live cell imaging with a RhoA-specific biosensor...
Topics
- Amides
- Apoptosis Regulatory Proteins
- Biosensing Techniques
- Cardiac Myosins
- Carrier Proteins
- Cell Line
- Endothelial Cells
- Hemangioma, Cavernous, Central Nervous System
- Humans
- KRIT1 Protein