Article
CCM2-deficient endothelial cells undergo a ROCK-dependent reprogramming into senescence-associated secretory phenotype.
Angiogenesis - 1 Nov 2021
Vannier Daphné Raphaëlle, Shapeti Apeksha, Chuffart Florent, Planus Emmanuelle, Manet Sandra, Rivier Paul, Destaing Olivier, Albiges-Rizo Corinne, Van Oosterwyck Hans, Faurobert Eva
Abstract excerpt
Cerebral cavernous malformation (CCM) is a cerebrovascular disease in which stacks of dilated haemorrhagic capillaries form focally in the brain. Whether and how defective mechanotransduction, cellular mosaicism and inflammation interplay to sustain the progression of CCM disease is unknown. Here...
Topics
- Carrier Proteins
- Endothelial Cells
- Hemangioma, Cavernous, Central Nervous System
- Humans
- Mechanotransduction, Cellular
- Phenotype
- Senescence-Associated Secretory Phenotype
- Tumor Microenvironment