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Article

CCM2-deficient endothelial cells undergo a ROCK-dependent reprogramming into senescence-associated secretory phenotype.

Angiogenesis - 1 Nov 2021

Vannier Daphné Raphaëlle, Shapeti Apeksha, Chuffart Florent, Planus Emmanuelle, Manet Sandra, Rivier Paul, Destaing Olivier, Albiges-Rizo Corinne, Van Oosterwyck Hans, Faurobert Eva

Abstract excerpt

Cerebral cavernous malformation (CCM) is a cerebrovascular disease in which stacks of dilated haemorrhagic capillaries form focally in the brain. Whether and how defective mechanotransduction, cellular mosaicism and inflammation interplay to sustain the progression of CCM disease is unknown. Here, we reveal that CCM1- and CCM2-silenced endothelial cells expanded in vitro enter into senescence-associated secretory...

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PMID: 34342749
DOI: 10.1007/s10456-021-09809-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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