Article
Evidence for anti-angiogenic and pro-survival functions of the cerebral cavernous malformation protein 3.
Neurogenetics - 1 Feb 2011
Schleider Elisa, Stahl Sonja, Wüstehube Joycelyn, Walter Ulrich, Fischer Andreas, Felbor Ute
Abstract excerpt
Mutations in CCM1, CCM2, or CCM3 lead to cerebral cavernous malformations, one of the most common hereditary vascular diseases of the brain. Endothelial cells within these lesions are the main disease compartments. Here, we show that adenoviral CCM3 expression inhibits endothelial cell migration, proliferation, and tube formation while downregulation of endogenous CCM3 results in increased formation of tube-like...
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