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Article

Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity.

The Journal of experimental medicine - 12 Apr 2010

Stockton Rebecca A, Shenkar Robert, Awad Issam A, Ginsberg Mark H

Abstract excerpt

Endothelial cell-cell junctions regulate vascular permeability, vasculogenesis, and angiogenesis. Familial cerebral cavernous malformations (CCMs) in humans result from mutations of CCM2 (malcavernin, OSM, MGC4607), PDCD10 (CCM3), or KRIT1 (CCM1), a Rap1 effector which stabilizes endothelial cell-cell junctions. Homozygous loss of KRIT1 or CCM2 produces lethal vascular phenotypes in mice and zebrafish. We report...

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Identifiers

PMID: 20308363
DOI: 10.1084/jem.20091258
PMCID: PMC2856024

Genes

CCM2
OSM
PDCD10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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