Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory.

doi:10.1073/pnas.0707106104

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Article

Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory.

Proceedings of the National Academy of Sciences of the United States of America - 18 Dec 2007

Zhang Ying, Bertolino Alessandro, Fazio Leonardo, Blasi Giuseppe, Rampino Antonio, Romano Raffaella, Lee Mei-Ling T, Xiao Tao, Papp Audrey, Wang Danxin, Sadée Wolfgang

Abstract excerpt

Subcortical dopamine D2 receptor (DRD2) signaling is implicated in cognitive processes and brain disorders, but the effect of DRD2 variants remains ambiguous. We measured allelic mRNA expression in postmortem human striatum and prefrontal cortex and then performed single nucleotide polymorphism (SNP) scans of the DRD2 locus. A previously uncharacterized promoter SNP (rs12364283) located in a conserved suppressor...

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PMID: 18077373
DOI: 10.1073/pnas.0707106104
PMCID: PMC2154469

Genes

DRD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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