Article
SJLB mice develop tauopathy-induced parkinsonism.
Neuroscience letters - 12 Apr 2010
Takenokuchi Mariko, Kadoyama Keiichi, Chiba Shunmei, Sumida Miho, Matsuyama Shogo, Saigo Katsuyasu, Taniguchi Taizo
Abstract excerpt
Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is an inherited dementia caused by tauopathy. Recently, we established the N279K mutant human tau transgenic mice SJLB. Although SJLB mice show cognitive dysfunction with insoluble tau in the brain, it has remained unclear...
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