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Article

Locomotor differences in mice expressing wild-type human α-synuclein.

Neurobiology of aging - 1 May 2018

Giraldo Genesys, Brooks Mieu, Giasson Benoit I, Janus Christopher

Abstract excerpt

Parkinson's disease manifests as a progressive movement disorder with underlying degeneration of dopaminergic neurons in the substantia nigra, consequent depletion of dopamine levels, and the accumulation of Lewy bodies in the brain. Because α-synuclein (α-Syn) protein is the major component of Lewy bodies, mouse models expressing wild-type or mutant SNCA/α-Syn genes provide a useful tool to investigate canonical...

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Identifiers

PMID: 29477894
DOI: 10.1016/j.neurobiolaging.2018.01.020
PMCID: PMC5871592

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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