Article
Suppression of Parkin enhances nigrostriatal and motor neuron lesion in mice over-expressing human-mutated tau protein.
Human molecular genetics - 1 Jul 2006
Menéndez J, Rodríguez-Navarro J A, Solano R M, Casarejos M J, Rodal I, Guerrero R, Sánchez M P, Avila J, Mena M A, de Yébenes J G
Abstract excerpt
Abnormal deposition of protein tau takes place in the brain of patients with several neurodegenerative diseases. Few of these patients present frontotemporal dementia with parkinsonism and amyotrophy (FTDPA-17), an autosomal dominant tauopathy related to mutations of the gene that codes for protein tau, localized in chromosome 17. The great majority of patients with tauopathies such as Alzheimer's disease,...
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