FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain.

doi:10.1006/mcne.2001.1051

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FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain.

Molecular and cellular neurosciences - 1 Dec 2001

Lim F, Hernández F, Lucas J J, Gómez-Ramos P, Morán M A, Avila J

Abstract excerpt

The tauopathies, which include Alzheimer's disease (AD) and frontotemporal dementias, are a group of neurodegenerative disorders characterized by filamentous Tau aggregates. That Tau dysfunction can cause neurodegeneration is indicated by pathogenic tau mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). To investigate how Tau alterations provoke neurodegeneration we generated...

Topics

Acid Phosphatase
Animals
Cerebral Cortex
Cytoskeleton
Female
Hippocampus
Humans
Immunohistochemistry
Lysosomes
Male
Mice
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microscopy, Electron

Mutation

Neuroblastoma

Neurodegenerative Diseases

Neurons

Phosphorylation

Source

Open in PubMed

Identifiers

PMID: 11749044
DOI: 10.1006/mcne.2001.1051

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