Article
The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities.
Molecular neurodegeneration - 25 Apr 2012
Maekawa Tatsunori, Mori Sayuri, Sasaki Yui, Miyajima Takashi, Azuma Sadahiro, Ohta Etsuro, Obata Fumiya
Abstract excerpt
BACKGROUND: Leucine-rich repeat kinase 2 (LRRK2) is the gene responsible for autosomal-dominant Parkinson's disease (PD), PARK8, but the mechanism by which LRRK2 mutations cause neuronal dysfunction remains unknown. In the present study, we investigated for the first time a transgenic (TG) mouse strain expressing human LRRK2 with an I2020T mutation in the kinase domain, which had been detected in the patients of...
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