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Article

Frontotemporal dementia with Parkinsonism linked to chromosome-17 mutations enhance tau oligomer formation.

Neurobiology of aging - 1 Sept 2018

Maeda Sumihiro, Sato Yuhei, Takashima Akihiko

Abstract excerpt

The P301 L mutation in tau, a microtubule-associated protein, causes frontotemporal dementia with Parkinsonism linked to chromosome-17 (FTDP-17) that is accompanied by formation of filamentous polymers of tau. The mutation reduces the binding capability of microtubules and enhances tau filament formation. However, it is unclear whether the P301 L mutation increases the formation of the intermediates of tau...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29852407
DOI: 10.1016/j.neurobiolaging.2018.04.014

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