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Article

Loss of dopaminoreceptive neuron causes L-dopa resistant parkinsonism in tauopathy.

Neurobiology of aging - 1 Oct 2012

Chiba Shunmei, Takada Erika, Tadokoro Mamoru, Taniguchi Taizo, Kadoyama Keiichi, Takenokuchi Mariko, Kato Seiya, Suzuki Noboru

Abstract excerpt

Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is a family of inherited dementias caused by tauopathy. A mutation in exon 10 of the tau gene, N279K, causes a particular kindred of FTDP-17, which is predominant for parkinsonism. The disease initially presents as L-dopa resistant parkinsonism which then rapidly progresses. The final pathological features reveal disappearing dopamine (DA)...

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PMID: 22169201
DOI: 10.1016/j.neurobiolaging.2011.11.002

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