Real-time in vivo imaging of p16Ink4a gene expression: a new approach to study senescence stress signaling in living animals

Abstract excerpt

Oncogenic proliferative signals are coupled to a variety of growth inhibitory processes. In cultured primary human fibroblasts, for example, ectopic expression of oncogenic Ras or its downstream mediator initiates cellular senescence, the state of irreversible cell cycle arrest, through up-regulation of cyclin-dependent kinase (CDK) inhibitors, such as p16(INK4a). To date, much of our current knowledge of how...

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