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Article

Efficient immortalization of primary human cells by p16<sup>INK4a</sup>‐specific short hairpin RNA or Bmi‐1, combined with introduction of hTERT

8 Dec 2006

Abstract excerpt

Activation of telomerase is sufficient for immortalization of some types of human cells but additional factors may also be essential. It has been proposed that stress imposed by inadequate culture conditions induces senescence due to accumulation of p16(INK4a). Here, we present evidence that many human cell types undergo senescence by activation of the p16(INK4a)/Rb pathway, and that introduction of Bmi-1 can...

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Share to Epigenetics and DNA Methylation
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PMID: 17233832
DOI: 10.1111/j.1349-7006.2006.00373.x

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