Real‐time imaging of transcriptional activation in live cells reveals rapid up‐regulation of the cyclin‐dependent kinase inhibitor gene CDKN1A in replicative cellular senescence

Abstract excerpt

Cellular replicative senescence is a permanent growth arrest state that can be triggered by telomere shortening. The cyclin-dependent kinase (Cdk) inhibitor p21(CIP1/WAF1) (p21), encoded by the CDKN1A gene, is a critical cell cycle regulator whose expression increases as cells approach senescence. Although the pathways responsible for its up-regulation are not well understood, compelling evidence indicates that...