Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?

1 Aug 2006

Abstract excerpt

Cellular senescence, the irreversible proliferative arrest seen in somatic cells after a limited number of divisions, is considered a crucial barrier to cancer, but direct evidence for this in vivo was lacking until recently. The best-known form of human cell senescence is attributed to telomere shortening and a DNA-damage response through p53 and p21. There is also a more rapid form of senescence, dependent on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to melanin and skin pigmentation
Share to Ocular Oncology and Treatments
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16880792
DOI: 10.1038/sj.bjc.6603283

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?PMID 16880792Read ↗

p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression.Semantic proximity Read ↗

The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescenceSemantic proximity Read ↗

Melanomagenesis: Overcoming the barrier of melanocyte senescenceSemantic proximity Read ↗

Senescence-Like Phenotypes in Human Nevi.Semantic proximity Read ↗

Genetics of melanoma progression: the rise and fall of cell senescence.Semantic proximity Read ↗

Molecular Regulation of Melanocyte SenescenceSemantic proximity Read ↗

p16INK4a-induced senescence is disabled by melanoma-associated mutations.Semantic proximity Read ↗

Oncogene‐induced senescence and melanoma: where do we stand?Semantic proximity Read ↗

Human melanocyte senescence and melanoma susceptibility genes.Semantic proximity Read ↗

Review: Are moles senescent?Semantic proximity Read ↗

Distinct senescence mechanisms restrain progression of dysplastic neviSemantic proximity Read ↗

A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.