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Article

Fitness epistasis and constraints on adaptation in a human immunodeficiency virus type 1 protein region.

Genetics - 1 May 2010

da Silva Jack, Coetzer Mia, Nedellec Rebecca, Pastore Cristina, Mosier Donald E

Abstract excerpt

Fitness epistasis, the interaction among alleles at different loci in their effects on fitness, has potentially important consequences for adaptive evolution. We investigated fitness epistasis among amino acids of a functionally important region of the human immunodeficiency virus type 1 (HIV-1) exterior envelope glycoprotein (gp120). Seven mutations putatively involved in the adaptation of the second conserved...

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Share to Adaptation, Physiological
Share to Epistasis, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Genetic Fitness

Share to HIV Envelope Protein gp120

Share to Receptors, CCR5

Share to Receptors, CXCR4

Source

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Identifiers

PMID: 20157005
DOI: 10.1534/genetics.109.112458
PMCID: PMC2870964

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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