Article
Fitness epistasis and constraints on adaptation in a human immunodeficiency virus type 1 protein region.
Genetics - 1 May 2010
da Silva Jack, Coetzer Mia, Nedellec Rebecca, Pastore Cristina, Mosier Donald E
Abstract excerpt
Fitness epistasis, the interaction among alleles at different loci in their effects on fitness, has potentially important consequences for adaptive evolution. We investigated fitness epistasis among amino acids of a functionally important region of the human immunodeficiency virus type 1 (HIV-1) exterior envelope glycoprotein (gp120). Seven mutations putatively involved in the adaptation of the second conserved...
Topics
- Adaptation, Physiological
- Amino Acid Sequence
- Epistasis, Genetic
- Evolution, Molecular
- Genetic Fitness
- HIV Envelope Protein gp120
- HIV-1
- Humans
- Molecular Sequence Data
- Mutation
- Receptors, CCR5
- Receptors, CXCR4