Article
A comprehensive biophysical description of pairwise epistasis throughout an entire protein domain.
Current biology : CB - 17 Nov 2014
Olson C Anders, Wu Nicholas C, Sun Ren
Abstract excerpt
BACKGROUND: Nonadditivity in fitness effects from two or more mutations, termed epistasis, can result in compensation of deleterious mutations or negation of beneficial mutations. Recent evidence shows the importance of epistasis in individual evolutionary pathways. However, an unresolved question in molecular evolution is how often and how significantly fitness effects change in alternative genetic backgrounds....
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