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Article

Human immunodeficiency virus type 1 coreceptor switching: V1/V2 gain-of-fitness mutations compensate for V3 loss-of-fitness mutations.

Journal of virology - 1 Jan 2006

Pastore C, Nedellec R, Ramos A, Pontow S, Ratner L, Mosier D E

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) entry into target cells is mediated by the virus envelope binding to CD4 and the conformationally altered envelope subsequently binding to one of two chemokine receptors. HIV-1 envelope glycoprotein (gp120) has five variable loops, of which three (V1/V2...

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Share to Cell Line
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, CCR5

Share to Receptors, CXCR4

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Source

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Identifiers

PMID: 16378977
DOI: 10.1128/JVI.80.2.750-758.2006
PMCID: PMC1346864

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16378977-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Human immunodeficiency virus type 1 coreceptor switching: V1/V2 gain-of-fitness mutations compensate for V3 loss-of-fitness mutations.PMID 16378977Read ↗

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