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Article

Evidence for positive epistasis in HIV-1.

Science (New York, N.Y.) - 26 Nov 2004

Bonhoeffer Sebastian, Chappey Colombe, Parkin Neil T, Whitcomb Jeanette M, Petropoulos Christos J

Abstract excerpt

Reproductive strategies such as sexual reproduction and recombination that involve the shuffling of parental genomes for the production of offspring are ubiquitous in nature. However, their evolutionary benefit remains unclear. Many theories have identified potential benefits, but progress is hampered by the scarcity of relevant data. One class of theories is based on the assumption that mutations affecting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15567861
DOI: 10.1126/science.1101786

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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