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Strains of the East Asian (W/Beijing) Lineage ofMycobacterium tuberculosisAre DosS/DosT-DosR Two-Component Regulatory System Natural Mutants

13 Feb 2010

Abstract excerpt

As part of our ongoing efforts to uncover the phenotypic consequences of genetic variability among clinical Mycobacterium tuberculosis isolates, we previously reported that isolates of the "East Asian" or "W/Beijing" lineage constitutively overexpress the coordinately regulated transcriptional program known as the DosR regulon under standard in vitro conditions. This phenotype distinguishes the W/Beijing lineage...

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PMID: 20154135
DOI: 10.1128/jb.01597-09

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