Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Behavioral analyses of transgenic mice harboring bipolar disorder candidate genes, IMPA1 and IMPA2.

Neuroscience research - 1 May 2010

Ohnishi Tetsuo, Watanabe Akiko, Ohba Hisako, Iwayama Yoshimi, Maekawa Motoko, Yoshikawa Takeo

Abstract excerpt

The inositol depletion hypothesis proposes the inhibition of IMPase (myo-inositol monophosphatase) by lithium, a mood stabilizer, as a mechanism of lithium's efficacy. This hypothesis predicts that the upregulation of this biochemical pathway may underlie the pathophysiology of bipolar disorder....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antidepressive Agents
Share to Antimanic Agents
Share to Avoidance Learning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bipolar Disorder

Share to Maze Learning

Share to Motor Activity

Share to Phosphoric Monoester Hydrolases

Source

Identifiers

PMID: 20153384
DOI: 10.1016/j.neures.2010.02.003

Genes

IMPA2
IMPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20153384-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Behavioral analyses of transgenic mice harboring bipolar disorder candidate genes, IMPA1 and IMPA2.PMID 20153384Read ↗

A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription.Semantic proximity Read ↗

A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic-depressive patients.Semantic proximity Read ↗

Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis.Semantic proximity Read ↗

Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder.Semantic proximity Read ↗

SMIT1 haploinsufficiency causes brain inositol deficiency without affecting lithium-sensitive behavior.Semantic proximity Read ↗

A new mouse model for mania shares genetic correlates with human bipolar disorder.Semantic proximity Read ↗

Association analysis between polymorphisms in the myo-inositol monophosphatase 2 (IMPA2) gene and bipolar disorder.Semantic proximity Read ↗

Behavioural phenotyping of sodium-myo-inositol cotransporter heterozygous knockout mice with reduced brain inositol.Semantic proximity Read ↗

Genomic structure and novel variants of myo-inositol monophosphatase 2 (IMPA2).Semantic proximity Read ↗

Homozygote inositol transporter knockout mice show a lithium-like phenotype.Semantic proximity Read ↗

Microarray gene expression profiling of mouse brain mRNA in a model of lithium treatmentSemantic proximity Read ↗

Lithium reverses behavioral and axonal transport-related changes associated with ANK3 bipolar disorder gene disruption.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.