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Article

SMIT1 haploinsufficiency causes brain inositol deficiency without affecting lithium-sensitive behavior.

Molecular genetics and metabolism - 1 Aug 2006

Shaldubina Alona, Johanson Roy A, O'Brien W Timothy, Buccafusca Roberto, Agam Galila, Belmaker R H, Klein Peter S, Bersudsky Yuly, Berry Gerard T

Abstract excerpt

Two leading hypotheses to explain lithium action in bipolar disorder propose either inositol depletion or inhibition of GSK-3 as mechanisms of action. Behavioral effects of lithium are mimicked in Gsk-3beta+/- mice, but the contribution of inositol depletion to these behaviors has not been tested. According to the inositol depletion hypothesis, lithium-sensitive behavior is secondary to impaired...

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Identifiers

PMID: 16644257
DOI: 10.1016/j.ymgme.2006.03.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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