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Article

Microarray gene expression profiling of mouse brain mRNA in a model of lithium treatment

1 Apr 2008

Abstract excerpt

OBJECTIVES: Even after five decades of use, the mood stabilizer lithium continues to be the mainstay of treatment for bipolar disorder in many countries. The mechanism of action for lithium, however, remains unclear. METHODS: In this study, microarray analysis was used to identify genes and cellular pathways that are altered in the mouse brain after treatment with lithium at human therapeutic concentrations. Mice...

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PMID: 18349697
DOI: 10.1097/ypg.0b013e3282fb0051

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