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Article

Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis.

The Journal of biological chemistry - 11 Apr 2014

Ohnishi Tetsuo, Murata Takuya, Watanabe Akiko, Hida Akiko, Ohba Hisako, Iwayama Yoshimi, Mishima Kazuo, Gondo Yoichi, Yoshikawa Takeo

Abstract excerpt

myo-Inositol is an essential biomolecule that is synthesized by myo-inositol monophosphatase (IMPase) from inositol monophosphate species. The enzymatic activity of IMPase is inhibited by lithium, a drug used for the treatment of mood swings seen in bipolar disorder. Therefore, myo-inositol is thought to have an important role in the mechanism of bipolar disorder, although the details remain elusive. We screened...

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Identifiers

PMID: 24554717
DOI: 10.1074/jbc.M113.536706
PMCID: PMC4036449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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