Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lithium reverses behavioral and axonal transport-related changes associated with ANK3 bipolar disorder gene disruption.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Mar 2017

Gottschalk Michael G, Leussis Melanie P, Ruland Tillmann, Gjeluci Klaudio, Petryshen Tracey L, Bahn Sabine

Abstract excerpt

Ankyrin 3 (ANK3) has been implicated as a genetic risk factor for bipolar disorder (BD), however the resulting pathophysiological and treatment implications remain elusive. In a preclinical systems biological approach, we aimed to characterize the behavioral and proteomic effects of Ank3 haploinsufficiency and chronic mood-stabilizer treatment in mice. Psychiatric-related behavior was evaluated with the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ankyrins
Share to Antimanic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Avoidance Learning

Share to Axonal Transport

Share to Glutamic Acid

Share to Maze Learning

Share to Mental Disorders

Share to Tandem Mass Spectrometry

Source

Identifiers

PMID: 28109561
DOI: 10.1016/j.euroneuro.2017.01.001

Genes

ANK3
NSF
SRM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lithium reverses behavioral and axonal transport-related changes associated with ANK3 bipolar disorder gene disruption.PMID 28109561Read ↗

Ankyrin 3: genetic association with bipolar disorder and relevance to disease pathophysiologySemantic proximity Read ↗

Behavioural characterization of AnkyrinG deficient mice, a model for ANK3 related disorders.Semantic proximity Read ↗

Lithium drives coordinated changes in the mouse synaptic phosphoproteomeSemantic proximity Read ↗

Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorderSemantic proximity Read ↗

Decreased neuronal Na+, K+ -ATPase activity in Atp1a3 heterozygous mice increases susceptibility to depression-like endophenotypes by chronic variable stress.Semantic proximity Read ↗

Ankyrin-G isoform imbalance and interneuronopathy link epilepsy and bipolar disorder.Semantic proximity Read ↗

Altered Protein Phosphorylation in a Novel Midbrain Organoid Model for Bipolar DisorderSemantic proximity Read ↗

Lithium treatment drives coordinated multi-kinase remodelling of the mouse synaptic phosphoproteomeSemantic proximity Read ↗

Cognitive deficits caused by a disease-mutation in the α3 Na(+)/K(+)-ATPase isoform.Semantic proximity Read ↗

GSK3B inhibition partially reverses brain ethanol-induced transcriptomic changes in C57BL/6J mice: Expression network co-analysis with human genome-wide association studiesSemantic proximity Read ↗

Lithium partially rescues gene expression and enhancer activity from heterozygous knockout of <i>AKAP11</i> while inducing novel differential changesSemantic proximity Read ↗

Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.