A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription.

doi:10.1038/sj.npp.1301307

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 2007

Ohnishi Tetsuo, Yamada Kazuo, Ohba Hisako, Iwayama Yoshimi, Toyota Tomoko, Hattori Eiji, Inada Toshiya, Kunugi Hiroshi, Tatsumi Masahiko, Ozaki Norio, Iwata Nakao, Sakamoto Kaoru, Iijima Yoshimi, Iwata Yasuhide, Tsuchiya Kenji J, Sugihara Genichi, Nanko Shinichiro, Osumi Noriko, Detera-Wadleigh Sevilla D, Kato Tadafumi, Yoshikawa Takeo

Abstract excerpt

Lithium is an effective mood stabilizer for bipolar disorder patients and its therapeutic effect may involve inhibition of inositol monophosphatase activity. In humans, the enzyme is encoded by two genes, IMPA1 and IMPA2. IMPA2 maps to 18p11.2, a genomic interval for which evidence of linkage to bipolar disorder has been supported by several reports. We performed a genetic association study in Japanese cohorts...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bipolar Disorder

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 18

Share to Lithium Chloride

Share to Neuroblastoma

Share to Phosphoric Monoester Hydrolases

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Risk

Share to Transfection

Source

Open in PubMed

Identifiers

PMID: 17251911
DOI: 10.1038/sj.npp.1301307

Genes

IMPA2
IMPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription.PMID 17251911Read ↗

A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic-depressive patients.Semantic proximity Read ↗

Genomic structure and novel variants of myo-inositol monophosphatase 2 (IMPA2).Semantic proximity Read ↗

Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder.Semantic proximity Read ↗

A promoter polymorphism rs2075824 within IMPA2 gene affecting the transcription activity: possible relationship with schizophrenia.Semantic proximity Read ↗

Association analysis between polymorphisms in the myo-inositol monophosphatase 2 (IMPA2) gene and bipolar disorder.Semantic proximity Read ↗

Evidence for association of the myo-inositol monophosphatase 2 (IMPA2) gene with schizophrenia in Japanese samples.Semantic proximity Read ↗

Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures.Semantic proximity Read ↗

Behavioral analyses of transgenic mice harboring bipolar disorder candidate genes, IMPA1 and IMPA2.Semantic proximity Read ↗

A homozygous loss-of-function mutation in inositol monophosphatase 1 (IMPA1) causes severe intellectual disability.Semantic proximity Read ↗

C18orf1 located on chromosome 18p11.2 may confer susceptibility to schizophrenia.Semantic proximity Read ↗

Genetic Control of Lithium Sensitivity and Regulation of Inositol Biosynthetic GenesSemantic proximity Read ↗

IMPA1 dependent regulation of plasma membrane phosphatidylinositol 4,5-bisphosphate turnover and calcium signalling by lithiumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.