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Article

Homozygote inositol transporter knockout mice show a lithium-like phenotype.

Bipolar disorders - 1 Jun 2008

Bersudsky Yuly, Shaldubina Alona, Agam Galila, Berry Gerard T, Belmaker Robert H

Abstract excerpt

OBJECTIVE: Lithium inhibits inositol monophosphatase and also reduces inositol transporter function. To determine if one or more of these mechanisms might underlie the behavioral effects of lithium, we studied inositol transporter knockout mice. We previously reported that heterozygous knockout mice with reduction of 15-37% in brain inositol had no abnormalities of pilocarpine sensitivity or antidepressant-like...

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Identifiers

PMID: 18452441
DOI: 10.1111/j.1399-5618.2007.00546.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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